Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion–solvent diffusion

Microfluidic emulsification and sorting assisted preparation of monodisperse chitosan microparticles.

A microfluidic device for generating monodisperse chitosan microparticles and separating the desired particle from smaller particles created as a byproduct of this process was described. The purpose of this study is to separate the satellite droplets from their parent droplets to enhance the size uniformity of the desired microparticles. A double T-junction design was first employed to control ...

Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores

We use a perfluorinated-dendrimer–dye complex that stabilizes microbubbles as a novel pore-forming agent. We use microfluidics to produce monodisperse emulsions containing a polymer matrix material, a model active, and the perfluorinated complex; upon drying, the emulsions form porous microspheres. This porosity causes the encapsulated model active to be released faster than from non-porous mic...

Continuous-flow In-droplet Magnetic Particle Separation in a Droplet-based Microfluidic Platform

ABSTRACT We demonstrate a droplet-based microfluidic device in which in-droplet magnetic bead separation is performed in continuous-flow. Two droplets containing different solution for the magnetic bead separation are generated in pair-wise manner. Sequential fusion of droplets occurs by a geometrical structure. The magnetic beads are deflected by externally applied magnetic force from one side...

Pc 52 Design of a Polymer Dispersion Stabilizer for Preparation of Monodisperse Polylactide Microspheres

Monodisperse hydrogel microspheres by forced droplet formation in aqueous two-phase systems.

This paper presents a method to form micron-sized droplets in an aqueous two-phase system (ATPS) and to subsequently polymerize the droplets to produce hydrogel beads. Owing to the low interfacial tension in ATPS, droplets do not easily form spontaneously. We enforce the formation of drops by perturbing an otherwise stable jet that forms at the junction where the two aqueous streams meet. This ...